Drug amorphization and its molecular dispersion in the polymer matrix were verified by several solid-state studies. Results: HME with a high shear rate produced by the twin-screw system was successfully applied to prepare VST-loaded SD formulations. Pharmacokinetic study was performed in rats to estimate the oral absorption of VST. Drug release from the SD formulations was assessed at pH values of 1.2, 4.0, and 6.8. The thermodynamic state of the drug and its dispersion in the polymers were evaluated by solid-state studies, including Fourier-transform infrared, X-ray diffraction, and differential scanning calorimetry. Methods: HME process with twin-screw configuration for generating a high shear stress was used to prepare VST SD formulations. *These authors contributed equally to this workД«ackground: Soluplus В® (SP) and бґ…-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS)вЂ“based solid dispersion (SD) formulations were developed by hot-melt extrusion (HME) to improve oral bioavailability of valsartan (VST). Jae-Young Lee, 1,* Wie-Soo Kang, 2,* Jingpei Piao, 2 In-Soo Yoon, 3 Dae-Duk Kim, 1 Hyun-Jong Cho 4ДЎCollege of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 2School of Bioscience and Biotechnology, Kangwon National University, Chuncheon, 3College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam, 4College of Pharmacy, Kangwon National University, Chuncheon, Republic of Korea

Lethal vst team vr